Jithin Nair#

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Jithin Nair
Research Associate

My interest in neuroscience began in 2016 while pursuing a master’s dissertation on unconventional glycine-binding NMDA receptors and their role in learning and memory formation. In 2018 I moved to Bristol to start a PhD with Jeremy Henley and Jack, where I investigated the role of kainate receptors in the plasticity of AMPA receptors. In 2021 I joined the lab as a Postdoc.

Research:#

My research focuses on the role of ion channels in the network activity of brain circuits. I am interested in understanding the role of GluK2 pre-mRNA editing in maintaining healthy neuronal networks and its dysfunction in neurological and neurodevelopmental disorders.

I am also interested in the role that AMPA receptor function has on epileptogenesis.

To investigate these topics I utilize my biochemical skill-set with brain slice electrophysiology to study circuit function.

Current projects:#

 

Outside of the lab

  • I love to travel and take pictures of people, cities, landscapes, nature, and art forms.

  • Shooting: Bullseye and clay

  • Going for walks

  • Flying microlight

  • Listen to music whilst singing along

  • Cooking

  • And recently discovered- fragrance collection

 


Publications:#

GluK2 Q/R editing regulates kainate receptor signalling and synaptic AMPA receptor expression and function.
J Nair, K Wilkinson, C Mulle, B Vissel, J Mellor, J Henley
bioRxiv 2022 (article)

Surface biotinylation of primary neurons to monitor changes in AMPA receptor surface expression in response to kainate receptor stimulation
Jithin D. Nair, Jeremy M. Henley, Kevin A. Wilkinson
Star Protocols 2021 (article)

Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD
JD Nair, E Braksator, BP Yucel, A Fletcher-Jones, R Seager, JR Mellor, Zafar I Bashir, Kevin A Wilkinson, Jeremy M Henley
Iscience, 2021. (article)

Kainate and AMPA receptors in epilepsy: Cell biology, signalling pathways and possible crosstalk
Jeremy M Henley, Jithin D Nair, Richard Seager, Busra P Yucel, Gavin Woodhall, Benjamin S Henley, Karolina Talandyte, Hope I Needs, Kevin A Wilkinson
Neuropharmacology, 2021. (article)

Kainate Receptors and Synaptic Plasticity
JD Nair, KA Wilkinson, JM Henley, JR Mellor
Neuropharmacology, 2021. (article)

SUMOylation of synaptic and synapse‐associated proteins: An update
Jeremy M Henley, Richard Seager, Yasuko Nakamura, Karolina Talandyte, Jithin Nair, Kevin A Wilkinson
Journal of Neurochemistry, 2020. (article)