Publications#
2024
Hippocampal-dependent navigation in head-fixed mice using a floating real-world environment
Sarah A. Stuart, Jon Palacios-Filardo, Aleks Domanski, Matt Udakis, Ian Duguid, Matt W. Jones & Jack R. Mellor
Scientific Reports, 2024 (article)
Analysis of hippocampal synaptic function in a rodent model of early life stress
Wilkinson MP, Robinson ESJ and Mellor JR
Wellcome Open Res, 2024 (article)
APP fragment controls both ionotropic and non-ionotropic signaling of NMDA receptors
Dunot J, Moreno S, Gandin C, Pousinha PA, Amici M, Dupuis J, Anisimova M, Winschel A, Uriot M, Petshow SJ, Mensch M, Bethus I, Giudici C, Hampel H, Wefers B, Wurst W, Naumann R, Ashby MC, Laube B, Zito K, Mellor JR, Groc L, Willem M, Marie H.
Neuron, 2024 (article)
2023
A mild impairment in reversal learning in a bowl‐digging substrate deterministic task but not other cognitive tests in the Dlg2+/− rat model of genetic risk for psychiatric disorder
Simonas Griesius, Sophie Waldron, Katie A Kamenish, Nick Cherbanich, Lawrence S Wilkinson, Kerrie L. Thomas, Jeremy Hall, Jack R Mellor, Dominic M Dwyer, Emma S J Robinson
Genes, Brain and Behavior, 2023 (article)
GluK2 Q/R editing regulates kainate receptor signalling and long-term potentiation of AMPA receptors
JD Nair, KA Wilkinson, BP Yucel, C Mulle, B Vissel, J Mellor, JM Henley
iScience, 2023 (article)
2022
Single-phase deep learning in cortico-cortical networks
Will Greedy, Heng Wei Zhu, Joseph Pemberton, Jack Mellor, Rui Ponte Costa
NeurIPS, 2022 (article)
PDZD8 Disruption Causes Cognitive Impairment in Humans, Mice, and Fruit Flies
Al-Amri AH, Armstrong P, Amici M, Ligneul C, Rouse J, El-Asrag ME, Pantiru A, Vancollie VE, Ng HWY, Ogbeta JA, Goodchild K, Ellegood J, Lelliott CJ, Mullins JGL, Bretman A, Al-Ali R, Beetz C, Al-Gazali L, Al Shamsi A, Lerch JP, Mellor JR, Al Sayegh A, Ali M, Inglehearn CF, Clapcote SJ.
Biol Psychiatry, 2022 (article)
Reduced expression of the psychiatric risk gene DLG2 (PSD93) impairs hippocampal synaptic integration and plasticity
Griesius S, O’Donnell C, Waldron S, Thomas KL, Dwyer DM, Wilkinson LS, Hall J, Robinson ESJ, Mellor JR.
Neuropsychopharmacology, 2022 (article)
Acetylcholine Boosts Dendritic NMDA Spikes in a CA3 Pyramidal Neuron Model
Humphries R, Mellor JR, O’Donnell C.
Neuroscience, 2022 (article)
Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder
Waldron S, Pass R, Griesius S, Mellor JR, Robinson ESJ, Thomas KL, Wilkinson LS, Humby T, Hall J, Dwyer DM.
Genes Brain Behav, 2022 (article)
2021
Investigation of reward learning and feedback sensitivity in non-clinical participants with a history of early life stress
Wilkinson MP, Slaney CL, Mellor JR, Robinson ESJ.
PLoS One, 2021 (article)
Author Correction: Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits
Palacios-Filardo J, Udakis M, Brown GA, Tehan BG, Congreve MS, Nathan PJ, Brown AJH, Mellor JR.
Nat Commun, 2021 (article)
21st century excitatory amino acid research: A Q & A with Jeff Watkins and Dick Evans
Watkins JC, Evans RH, Bayés À, Booker SA, Gibb A, Mabb AM, Mayer M, Mellor JR, Molnár E, Niu L, Ortega A, Pankratov Y, Ramos-Vicente D, Rodríguez-Campuzano A, Rodríguez-Moreno A, Wang LY, Wang YT, Wollmuth L, Wyllie DJA, Zhuo M, Frenguelli BG.
Neuropharmacology, 2021 (article)
Separable actions of acetylcholine and noradrenaline on neuronal ensemble formation in hippocampal CA3 circuits
Prince LY, Bacon T, Humphries R, Tsaneva-Atanasova K, Clopath C, Mellor JR.
PLoS Comput Biol, 2021 (article)
Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD
Nair JD, Braksator E, Yucel BP, Fletcher-Jones A, Seager R, Mellor JR, Bashir ZI, Wilkinson KA, Henley JM.
iScience, 2021 (article)
Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits
Palacios-Filardo J, Udakis M, Brown GA, Tehan BG, Congreve MS, Nathan PJ, Brown AJH, Mellor JR.
Nat Commun, 2021 (article)
Kainate receptors and synaptic plasticity
Nair JD, Wilkinson KA, Henley JM, Mellor JR.
Neuropharmacology, 2021 (article)
2020
Noradrenaline Release from Locus Coeruleus Terminals in the Hippocampus Enhances Excitation-Spike Coupling in CA1 Pyramidal Neurons Via β-Adrenoceptors
Bacon TJ, Pickering AE, Mellor JR.
Cereb Cortex, 2020 (article)
Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output
Udakis M, Pedrosa V, Chamberlain SEL, Clopath C, Mellor JR.
Nat Commun, 2020 (article)
Comparison of acute treatment with delayed-onset versus rapid-acting antidepressants on effort-related choice behaviour
Griesius S, Mellor JR, Robinson ES.
Psychopharmacology (Berl), 2020 (article)
Comparison of conventional and rapid-acting antidepressants in a rodent probabilistic reversal learning task
Wilkinson MP, Grogan JP, Mellor JR, Robinson ESJ.
Brain Neurosci Adv, 2020 (article)
A Bayesian predictive approach for dealing with pseudoreplication
Lazic SE, Mellor JR, Ashby MC, Munafo MR.
Sci Rep, 2020 (article)
2019
Neuromodulation of hippocampal long-term synaptic plasticity
Palacios-Filardo J, Mellor JR.
Curr Opin Neurobiol, 2019 (article)
2018
Convergent Metabotropic Signaling Pathways Inhibit SK Channels to Promote Synaptic Plasticity in the Hippocampus
Tigaret CM, Chamberlain SEL, Sadowski JHLP, Hall J, Ashby MC, Mellor JR.
J Neurosci, 2018 (article)
Cortactin regulates endo-lysosomal sorting of AMPARs via direct interaction with GluA2 subunit
Parkinson GT, Chamberlain SEL, Jaafari N, Turvey M, Mellor JR, Hanley JG.
Sci Rep, 2018 (article)
2017
Acetylcholine modulates gamma frequency oscillations in the hippocampus by activation of muscarinic M1 receptors
Betterton RT, Broad LM, Tsaneva-Atanasova K, Mellor JR.
Eur J Neurosci, 2017 (article)
Coordinated Acetylcholine Release in Prefrontal Cortex and Hippocampus Is Associated with Arousal and Reward on Distinct Timescales
Teles-Grilo Ruivo LM, Baker KL, Conway MW, Kinsley PJ, Gilmour G, Phillips KG, Isaac JTR, Lowry JP, Mellor JR.
Cell Rep, 2017 (article)
2016
Neuromodulation of the Feedforward Dentate Gyrus-CA3 Microcircuit
Prince LY, Bacon TJ, Tigaret CM, Mellor JR.
Front Synaptic Neurosci, 2016 (article)
Assessment of Methods for the Intracellular Blockade of GABAA Receptors
Atherton LA, Burnell ES, Mellor JR.
PLoS One, 2016 (article)
Control of Ca2+ Influx and Calmodulin Activation by SK-Channels in Dendritic Spines
Griffith T, Tsaneva-Atanasova K, Mellor JR.
PLoS Comput Biol, 2016 (article)
Sharp-Wave Ripples Orchestrate the Induction of Synaptic Plasticity during Reactivation of Place Cell Firing Patterns in the Hippocampus
Sadowski JH, Jones MW, Mellor JR.
Cell Rep, 2016 (article)
Coordinated activation of distinct Ca(2+) sources and metabotropic glutamate receptors encodes Hebbian synaptic plasticity
Tigaret CM, Olivo V, Sadowski JHLP, Ashby MC, Mellor JR.
Nat Commun, 2016 (article)
Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus
Dennis SH, Pasqui F, Colvin EM, Sanger H, Mogg AJ, Felder CC, Broad LM, Fitzjohn SM, Isaac JT, Mellor JR.
Cereb Cortex, 2016 (article)
2015
Memory trace replay: the shaping of memory consolidation by neuromodulation
Atherton LA, Dupret D, Mellor JR.
Trends Neurosci, 2015 (article)
Clathrin-independent trafficking of AMPA receptors
Glebov OO, Tigaret CM, Mellor JR, Henley JM.
J Neurosci, 2015 (article)
2013
Cholinergic modulation of hippocampal network function
Teles-Grilo Ruivo LM, Mellor JR.
Front Synaptic Neurosci, 2013 (article)
The small GTPase Arf1 modulates Arp2/3-mediated actin polymerization via PICK1 to regulate synaptic plasticity
Rocca DL, Amici M, Antoniou A, Blanco Suarez E, Halemani N, Murk K, McGarvey J, Jaafari N, Mellor JR, Collingridge GL, Hanley JG.
Neuron, 2013 (article)
Long-term depression of synaptic kainate receptors reduces excitability by relieving inhibition of the slow afterhyperpolarization
Chamberlain SE, Sadowski JH, Teles-Grilo Ruivo LM, Atherton LA, Mellor JR.
J Neurosci, 2013 (article)
Wavelet transform-based de-noising for two-photon imaging of synaptic Ca2+ transients
Tigaret CM, Tsaneva-Atanasova K, Collingridge GL, Mellor JR.
Biophys J, 2013 (article)
2012
Putting plasticity in its place
Sadowski JH, Mellor JR.
Front Neurosci, 2012 (article)
Homeostatic synaptic scaling is regulated by protein SUMOylation
Craig TJ, Jaafari N, Petrovic MM, Jacobs SC, Rubin PP, Mellor JR, Henley JM.
J Biol Chem, 2012 (article)
SUMOylation and phosphorylation of GluK2 regulate kainate receptor trafficking and synaptic plasticity
Chamberlain SE, González-González IM, Wilkinson KA, Konopacki FA, Kantamneni S, Henley JM, Mellor JR.
Nat Neurosci, 2012 (article)
Inhibition of post-synaptic Kv7/KCNQ/M channels facilitates long-term potentiation in the hippocampus
Petrovic MM, Nowacki J, Olivo V, Tsaneva-Atanasova K, Randall AD, Mellor JR.
PLoS One, 2012 (article)
2011
Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosis
Konopacki FA, Jaafari N, Rocca DL, Wilkinson KA, Chamberlain S, Rubin P, Kantamneni S, Mellor JR, Henley JM.
Proc Natl Acad Sci U S A, 2011 (article)
Dentate gyrus granule cell firing patterns can induce mossy fiber long-term potentiation in vitro
Mistry R, Dennis S, Frerking M, Mellor JR.
Hippocampus, 2011 (article)
Oxygen/glucose deprivation induces a reduction in synaptic AMPA receptors on hippocampal CA3 neurons mediated by mGluR1 and adenosine A3 receptors
Dennis SH, Jaafari N, Cimarosti H, Hanley JG, Henley JM, Mellor JR.
J Neurosci, 2011 (article)
PICK1 inhibition of the Arp2/3 complex controls dendritic spine size and synaptic plasticity
Nakamura Y, Wood CL, Patton AP, Jaafari N, Henley JM, Mellor JR, Hanley JG.
EMBO J, 2011 (article)
Ripples make waves: binding structured activity and plasticity in hippocampal networks
Sadowski JH, Jones MW, Mellor JR.
Neural Plast, 2011 (article)
2010
Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels
Buchanan KA, Petrovic MM, Chamberlain SE, Marrion NV, Mellor JR.
Neuron, 2010 (article)
A Ca-Based Computational Model for NMDA Receptor-Dependent Synaptic Plasticity at Individual Post-Synaptic Spines in the Hippocampus
Rackham OJ, Tsaneva-Atanasova K, Ganesh A, Mellor JR.
Front Synaptic Neurosci, 2010 (article)
The activity requirements for spike timing-dependent plasticity in the hippocampus
Buchanan KA, Mellor JR.
Front Synaptic Neurosci, 2010 (article)
2009
Hippocampal place cell firing patterns can induce long-term synaptic plasticity in vitro
Isaac JT, Buchanan KA, Muller RU, Mellor JR.
J Neurosci, 2009 (article)
PICK1-mediated glutamate receptor subunit 2 (GluR2) trafficking contributes to cell death in oxygen/glucose-deprived hippocampal neurons
Dixon RM, Mellor JR, Hanley JG.
J Biol Chem, 2009 (article)
2008
Bidirectional activity-dependent plasticity of membrane potential and the influence on spiking in rat hippocampal dentate granule cells
Mistry R, Mellor JR.
Neuropharmacology, 2008 (article)
2007
The development of synaptic plasticity induction rules and the requirement for postsynaptic spikes in rat hippocampal CA1 pyramidal neurones
Buchanan KA, Mellor JR.
J Physiol, 2007 (article)
SUMOylation regulates kainate-receptor-mediated synaptic transmission
Martin S, Nishimune A, Mellor JR, Henley JM.
Nature, 2007 (article)
2006
Synaptic plasticity of kainate receptors
Mellor JR.
Biochem Soc Trans, 2006 (article)
2003
Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation
Schmitz D, Mellor J, Breustedt J, Nicoll RA.
Nat Neurosci, 2003 (article)
2002
Mediation of hippocampal mossy fiber long-term potentiation by presynaptic Ih channels
Mellor J, Nicoll RA, Schmitz D.
Science, 2002 (article)
2001
Synaptically released neurotransmitter fails to desensitize postsynaptic GABA(A) receptors in cerebellar cultures
Mellor JR, Randall AD.
J Neurophysiol, 2001 (article)
Presynaptic kainate receptors at hippocampal mossy fiber synapses
Schmitz D, Mellor J, Frerking M, Nicoll RA.
Proc Natl Acad Sci U S A, 2001 (article)
Contrasting localizations of MALS/LIN-7 PDZ proteins in brain and molecular compensation in knockout mice
Misawa H, Kawasaki Y, Mellor J, Sweeney N, Jo K, Nicoll RA, Bredt DS.
J Biol Chem, 2001 (article)
Presynaptic kainate receptor mediation of frequency facilitation at hippocampal mossy fiber synapses
Schmitz D, Mellor J, Nicoll RA.
Science, 2001 (article)
Hippocampal mossy fiber LTP is independent of postsynaptic calcium
Mellor J, Nicoll RA.
Nat Neurosci, 2001 (article)
2000
Somato-synaptic variation of GABA(A) receptors in cultured murine cerebellar granule cells: investigation of the role of the alpha6 subunit
Mellor JR, Wisden W, Randall AD.
Neuropharmacology, 2000 (article)
The taurine uptake inhibitor guanidinoethyl sulphonate is an agonist at gamma-aminobutyric acid(A) receptors in cultured murine cerebellar granule cells
Mellor JR, Gunthorpe MJ, Randall AD.
Neurosci Lett, 2000 (article)
Tonic benzodiazepine-sensitive GABAergic inhibition in cultured rodent cerebellar granule cells
Leao RM, Mellor JR, Randall AD.
Neuropharmacology, 2000 (article)
Kainate receptors and synaptic plasticity
Nicoll RA, Mellor J, Frerking M, Schmitz D.
Nature, 2000 (article)
The actions of synaptically released zinc at hippocampal mossy fiber synapses
Vogt K, Mellor J, Tong G, Nicoll R.
Neuron, 2000 (article)
1998
Properties of GABA(A) receptors in cultured rat oligodendrocyte progenitor cells
Williamson AV, Mellor JR, Grant AL, Randall AD.
Neuropharmacology, 1998 (article)
Mouse cerebellar granule cell differentiation: electrical activity regulates the GABAA receptor alpha 6 subunit gene
Mellor JR, Merlo D, Jones A, Wisden W, Randall AD.
J Neurosci, 1998 (article)
Voltage-dependent deactivation and desensitization of GABA responses in cultured murine cerebellar granule cells
Mellor JR, Randall AD.
J Physiol, 1998 (article)
1997
Frequency-dependent actions of benzodiazepines on GABAA receptors in cultured murine cerebellar granule cells
Mellor JR, Randall AD.
J Physiol, 1997 (article)
Ligand-gated ion channel subunit partnerships: GABAA receptor alpha6 subunit gene inactivation inhibits delta subunit expression
Jones A, Korpi ER, McKernan RM, Pelz R, Nusser Z, Mäkelä R, Mellor JR, Pollard S, Bahn S, Stephenson FA, Randall AD, Sieghart W, Somogyi P, Smith AJ, Wisden W.
J Neurosci, 1997 (article)